Seven United States Navy ships have been named USS Columbia, after the personification of the United States, also after the city of Columbia, South Carolina.
- A 44-gun frigate Columbia was under construction at the Washington Navy Yard, but was burned in 1814 to prevent capture by the British.
- The second Columbia was a captured Confederate screw steamer that ran aground in 1863.
- The third Columbia was an ironclad, also captured from the Confederates in 1865 and in use until June of that year(?).
- The fifth Columbia (AG-9) was originally the Great Northern, a troop transport, renamed in 1921 and used until 1922.
In 1792, Captain Robert Gray, in a privately-owned vessel named Columbia sent to the Pacific Northwest to trade for fur, discovered the Columbia River and named it after the ship; it later became the first American ship to circumnavigate the globe.
The Space Shuttle Columbia (OV-102), which flew 28 missions between 1981 and 2003, is occasionally referred to as USS Columbia; this is incorrect, however, as she was not a vessel of the United States Navy.